Why Top VCs Are Quietly Investing in These Emerging Sectors

The Hidden Playbook: Where Elite VCs Are Placing Their Next Big Bets

Written by

Michael Collins

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9 min

While the world focuses on headline-grabbing developments in AI, a more subtle realignment occurs among perceptive venture capitalists.

VC isn’t about chasing the obvious or history. It’s about identifying frontier opportunities poised for long-term impact. Many leading investors are pivoting toward some emerging arenas that haven’t yet hit the mainstream radar. At first glance, these moves appear opportunistic based upon a new administration. But look closer, and you’ll find a deliberate long-term strategy rooted in exclusivity, foresight, and pursuing transformative returns.

As one of the world’s most active VCs and co-investors alongside respected funds, Alumni Ventures (AV) enjoys a powerful perspective on these shifts. We’re noting forward-thinking VCs quietly deploying capital into four under-discussed sectors: crypto 2.0 infrastructure, next-wave energy solutions, highly specialized vertical AI platforms, and defense tech startups reshaping modern security.

In this blog, we’ll dive into those “stealth” sectors, explaining its attractiveness. We’ll also feature key deals we secured access to deals alongside leading VCs thanks to Alumni Ventures’ network, relationships, value-add, and more.

The Shift in Venture Capital

The world’s most revered VCs rarely telegraph their future moves, preferring to operate a step ahead of public discourse. In the last 12-18 months, AV’s internal tracking has revealed a meaningful uptick—an estimated 50%—in deal volume across crypto, energy scaling and grid modernization, AI solutions targeted at niche verticals, and cutting-edge defense tech startups poised to redefine national security strategies.

This recalibration is subtle but profound. Consider how certain elite funds — those known for early bets on now-iconic tech giants — have recently diversified their scouting missions. One well-known Silicon Valley firm told me they’ve shifted the internal research mix from a 70/30 split (general AI vs. niche sectors) to an almost 90% on verticals. One also sees the rapidly increasing number of energy, crypto, and defense startups attending demo days.

These moves reflect a reality of leading VCs: the biggest returns often count on spotting the next big thing before others.

Identifying AND Accessing

Investing in transformative sectors isn’t just about spotting opportunities—it’s about earning the right to participate. At AV, our access to high-quality deals results from drawing on our huge network of connections, demonstrating our ability to deliver beyond capital, having the referrals to prove our value add, and being a “no-friction” investor.

Securing allocation in highly competitive, oversubscribed rounds often requires navigating limited availability, aligning deeply with founders, and collaborating seamlessly with leading co-investors. These tight windows of opportunity demand bold conviction, strategic positioning, and relentless effort, ensuring AV consistently delivers high-impact investments to our community.

1. Crypto 2.0: Beyond Digital Stores of Value

Forget the hype cycles and price volatility that once defined the crypto conversation. Elite VCs are now staking positions in what might be called “Crypto 2.0”: infrastructure and institutional tooling that transcend digital asset speculation. These startups are building the trust layers, compliance frameworks, and authentication systems that large enterprises, financial institutions, and governments rely on to make crypto and blockchain integral parts of tomorrow’s economy.

At AV, our internal data shows a roughly 25% increase in commitments to crypto infrastructure and crypto-based practical solutions over the past year. The focus is on ventures solving concrete problems: secure cross-border micropayments, enterprise-grade custody solutions, asset authenticity verification, betting markets, and sophisticated regulatory compliance tools. Major financial institutions are unobtrusively running pilots, working with these innovators to integrate blockchain into their core operations.

As one respected VC partner told us, “The chatter around BTC price and meme stocks misses the point. We’re interested in the underlying tech that solves problems. Take betting markets. On-chain betting markets are way better than polls or other markets for those looking to hedge outcomes.” Our co-investments in this area have aligned us alongside top funds leading these rounds.

For high-risk, high-return investors, entering Crypto 2.0 means positioning ahead of a future where this technology underpins the world’s transactional fabric.

AV has built a focused portfolio at the forefront of the Crypto 2.0 movement, featuring standouts Babylon, Mysten Labs, and Analog, each accessed through rare and strategic opportunities:

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    Babylon:

    Provides cutting-edge security and staking infrastructure on the Bitcoin network. We co-invested thanks to strong relationships with Paradigm Capital, Galaxy, and others.
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    Mysten Labs:

    Developed Sui, a high-performance blockchain designed to scale Web3 applications. We accessed through AV’s differentiated network and supported with multiple investments, co-investing with leading crypto investors A16z and Jump Crypto.
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    Analog:

    Revolutionizing time data transfer across Web3 applications with its Proof-of-Time protocol. We co-invested with prestigious investor Khosla Ventures, gaining allocation through AV’s thematic focus on interoperability in blockchain.

2. Energy Revolution: The Next Wave

Beyond solar panels and electric vehicles, the true revolution in energy transformation lies in the infrastructure and scaling solutions that ensure the grid can handle new loads and storage demands. Instead of guessing which single technology will “win,” top VCs are applying a portfolio mindset. They’re backing ventures focused on various solutions for grid modernization, advanced energy storage, and intelligent software platforms that optimize supply and demand.

Over the past decade, observers ranging from leading economists to energy scholars have emphasized that secure, reliable, and plentiful energy underpins societal well-being. The U.S. and many Western nations have allowed critical energy infrastructure and innovation pipelines to lag. Meanwhile, countries like China press forward, scaling up everything from renewables to advanced transmission grids at a speed few imagined possible.

Investors and governments must embrace a broad portfolio of energy solutions to remain competitive and ensure a stable, thriving society.

AV boasts a robust portfolio that spans the entire spectrum of the Energy Revolution, with standouts including X-Energy, Radiant Nuclear, and Pacific Fusion:

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    X-Energy:

    Designer and engineer of nuclear reactors and fuel. Initial access was gained through AV’s close ties with an existing portfolio company whose Chairman also serves on X-Energy’s board. We captured follow-on allocation in a highly competitive round by maintaining strong relationships with leadership. Amazon led the round with a $300 million check.

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    Radiant Nuclear:

    Developed portable, small-scale nuclear reactors, which aim to provide clean, reliable power to remote locations; we secured competitive allocation through AV’s participation in nuclear ecosystem events, where we engaged with Radiant’s team. The round was led by DCVC and joined by top-tier funds and strategies such as a16z, Union Square Ventures, Founders Fund, Chevron, and others.

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    Pacific Fusion:

    A nuclear fusion startup is building a system to generate more fusion energy than it consumes. Gained early access to this stealth company’s fundraise by leveraging AV’s ecosystem-building reputation and efficient processes. Investors included General Catalyst, Lightspeed, premier climate investor Lowercarbon Capital, and strategic angels like Eric Schmidt and Ken Griffin.

3. Vertical AI: The Quiet Revolution

While much of the public discourse fixates on broad, general-purpose AI breakthroughs, the most transformative impact often occurs behind the scenes, where specialized solutions reshape entire industries. Leading AI scholars and veteran investors have noted that true technological leaps come not from one-size-fits-all models but from systems painstakingly tailored to a specific context such as healthcare diagnostics, aerospace maintenance, or retail logistics optimization. Here, vertical AI emerges as a critical differentiator, forging new efficiencies, driving down costs, and delivering measurable results that aren’t lost in the hype cycle.

Yet just as Western nations have been slow to modernize energy infrastructure, many industries have lagged in tapping into the full potential of vertical AI. Rapid adopters in certain global markets, from manufacturing hubs to emerging biotech clusters, are moving swiftly, pulling ahead in productivity and innovation. AV’s internal data shows a 20% year-over-year increase in vertical AI investments, highlighting growing recognition among top VCs that these targeted solutions underpin a more intelligent, competitive future.

Those who back these specialized platforms now position themselves at the cutting edge of efficiency, performance, and long-term value creation.

AV has built a focused portfolio at the forefront of the vertical AI revolution, featuring standouts like these:

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    Groq:

    Pioneering the delivery of lightning-fast AI inference for cloud and on-premise AI compute centers, fueling rapid iteration and innovation for vertical applications. Secured a position by leveraging AV’s strong co-investor relationships and deep industry expertise,. joining with strong investors such Social Capital and BlackRock.
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    Anomaly:

    Transformative AI-driven platform revolutionizing healthcare billing, claims adjudication, and payment processes, significantly enhancing efficiency and accuracy. We participated in a highly competitive opportunity thanks to a long-standing relationship with the founder and co-investors, co-investing with Sound Ventures, RRE, Link Ventures, and more.

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    Consensus:

    AI-powered search engine tailored for students, academics, and researchers, designed to revolutionize access to and utilization of research insights. thanks to our alumni network, we participated in an initial and in multiple pre-emptive follow-on rounds. Co-investors included Draper Associates, Union Square Ventures, as well as thematic AI angels Daniel Gross and Nat Friedman (investors in Perplexity, Eleven Labs, Character.ai, Pika).

4. Defense Tech: A New Model for Security and Innovation

Today’s security challenges are unlike yesterday’s. Instead of battleships and traditional arsenals, modern defense involves drones, electronic warfare systems, AI-driven threat detection, and advanced cyber-security management. Startups, once hesitant to engage in defense contracting, are now at the forefront, developing nimble, software-centric solutions that governments and private security firms increasingly demand.

Our internal data show a growing pipeline of defense tech investments. Nine “mil-tech unicorns”—venture-backed defense tech companies valued at over $1B — have already emerged, and experts predict a hundred more could follow. These innovators are upending procurement models that favored legacy players for decades, leading to a more dynamic, startup-driven ecosystem.

As a source close to a security-focused VC remarked, “The future of defense is agility and intelligence, not just hardware.” For alpha investors, this sector offers an exclusive arena where private-market deals can significantly influence the shaping of next-generation security solutions.

By collaborating with leading co-investors, AV ensures our community is well-positioned to capitalize on a space where change is rapid, profound, and potentially very lucrative.

AV has built a dynamic portfolio tackling the rapidly evolving landscape of defense technology — from robotics and space to the frontlines and school campuses — featuring these innovators.

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    Ghost Robotics:

    Redefining robotics with quadrupedal unmanned ground vehicles (Q-UGVs). Thanks to AV’s collaboration with leading co-investors and strong rapport with the founding team, we secured an initial investment and follow-on stakes, alongside In-Q-Tel, bringing the CIA’s DNA to the cap table.
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    Firestorm:

    Developer of mission-specific unmanned aerial systems (UAS). We leveraged AV’s credibility, investment track record, and strategic value-add to win a spot in a highly competitive and oversubscribed round led by NEA, with participation from Lockheed Martin.

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    ZeroEyes:

    Focusing on AI-driven threat detection for critical infrastructure and public safety. We secured priority access to a stealth round via our extensive community network in a round led by Sorenson Capital and joined by Intel Capital.

Why What’s Next Matters

Early entrants stand to gain a crucial advantage in Crypto 2.0, Energy Revolution, Vertical AI, and Defense Tech. Market timing indicators — rising pilot programs, talent migrating from Big Tech and government labs, and incremental regulatory shifts — suggest that these fields are nearing inflection points.

Historical patterns show that those who move in before the world catches up enjoy more favorable valuations, stronger negotiating positions, and access to follow-on rounds. This is precisely what alpha investors seek: being “in” on potential big wins before these domains hit the mainstream narrative.

As one AV super-angel aid me, “You can pay a premium later when everyone knows the story, or you can write the opening chapters.” These opportunities won’t stay quiet forever. The window to securing a front-row seat at the next era of innovation is open now.

Learn More About the U.S. Strategic Tech Fund

We are seeing strong interest in our U.S. Strategic Tech Fund. If interested, we recommend securing a spot promptly.

Invest in technologies vital to U.S. national interests in a portfolio of ~15-20 venture investments made over ~12-18 months — diversified by stage, sector, geography, lead investor.

Max Accredited Investor Limit: 249

Conclusion and Investment Implications

The smartest VCs aren’t abandoning AI or other industries but layering in a strategic portfolio of quieter, emerging arenas. Our broad vantage point at AV — co-investing with many leading firms and accessing off-market opportunities — positions our community to act now across sectors.

If you’re intrigued by these under-the-radar domains, consider connecting with AV. Whether exploring our network, scheduling a call, or subscribing to our exclusive insights, this is your chance to align with the elite investors quietly shaping tomorrow’s landscape. When the headlines finally catch up, you’ll already be there.

Michael Collins
Michael Collins
CEO, Alumni Ventures

Mike is the CEO and Founder of Alumni Ventures. He has been involved in almost every facet of venturing, from angel investing to venture capital, new business and product launches, and innovation consulting. He began his career at VC firm TA Associates. He holds an undergraduate degree in Engineering Science from Dartmouth and an MBA from Harvard Business School.

This communication is neither and offer to sell, nor a solicitation of an offer to purchase, any security. Such offers are made only pursuant to the formal offering documents of the funds concerned, which describe the risks (which are significant), terms, and other important information that must be carefully considered before an investment is made. For more information, please see here.

Portfolio companies shown for illustrative purposes only. Not necessarily indicative of investments by any AV fund or investor. Example companies shown are not available to future investors, except potentially in the case of follow-on investments.

This communication includes forward-looking statements, generally consisting of any statement pertaining to any issue other than historical fact, including without limitation predictions, financial projections, the anticipated results of the execution of any plan or strategy, the expectation or belief of the speaker, or other events or circumstances to exist in the future. Forward looking statements are not representations of actual fact, depend on certain assumptions that may not be realized, and are not guaranteed to occur. Any forward-looking statements included in this communication speak only as of the date of the communication. AV and its affiliates disclaim any obligation to update, amend, or alter such forward-looking statements whether due to subsequent events, new information, or otherwise.